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Lit., "when [or "although"] thou wert nothing". This stress on God's unlimited power to bring into being a new chain of causes and effects forms here, as in Al 'Imran, a preamble to the announcement, expressed in very similar terms, of the birth of Jesus (see verses {19} ff.).
Who is the "He" in this clause? As I have construed it, following the majority of Commentators, it means the angel who brought the message from Allah. Cf. xix. 21 below. But some Commentators construe it to refer to Zakariya. In that case the meaning will be: Zakariya after a little reflection said (in his wonder) "So!", i.e., "Can it really be so? Can I really have a son in my old age?" The speech following,"Thy Lord saith," etc., will then be that of the angel-messenger.
Every man was nothing just before he was created, i.e., his personality was called into being by Allah. Even if there are material processes in forming the body, in accordance with the laws of nature, the real creative force is the power of Allah. But here there is a subtler meaning. John was the harbinger of Jesus, preparing the way for him; and this sentence also prepares us for the more wonderful birth of Jesus himself, see verse 21 below. Everything is possible with Allah.