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I.e., in the words of Razi, "towards self-surrender to God's will...[and so] towards gratitude in times of ease, and patience in times of misfortune". It is also possible - as some of the commentators do - to understand the phrase in another sense, namely, "if anyone believes in God, He [i.e., God] guides his heart". However, the rendering adopted by me seems to be preferable inasmuch as it stresses the idea that consious belief in God impels man's reason to control and direct his emotions and inclinations in accordance with all that this belief implies.
What we consider calamities may be blessings in disguise. Pain in the body is often a signal of something wrong, which we can cure by remedial measures. So in the moral and spiritual world, we should in all circumstances hold firmly to the faith that nothing happens without Allah's knowledge and leave; and therefore there must be some justice and wisdom according to His great universal Plan. Our duty is to find out our own shortcomings and remedy them. If we try to do so in all sincerity of heart, Allah will give us guidance.