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Contrary to many of the commentators who take this reference to "apes and swine" in a literal sense, the famous tabi'i Mujahid explains it as a metaphorical description (mathal) of the moral degradation which such sinners undergo: they become wildly unpredictable like apes, and as abandoned to the pursuit of lusts as swine (Manar VI, 448). This interpretation has also been quoted by Tabari in his commentary on 2:65 . - As regards the expression "powers of evil" (at-taghut), see surah {2}, note [250].
As is evident from the following verses, the sinners who are even worse than the mockers are the hypocrites, and particularly those among them who claim to be followers of the Bible: for the obvious reason that, having been enlightened through revelation, they have no excuse for their behaviour. Although in verse {64} the Jews are specifically mentioned, the reference to the Gospel in verse {66} makes it clear that the Christians, too, cannot be exempted from this blame.
Literally or metaphorically. See footnote for 2:65.
For apes see Q. ii. 65. For men possessed by devils, and the devils being sent into swine, see Matt. viii. 28-32.