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I.e., in the midst of their habitual occupations. My interpolation of the word "suddenly" is warranted by the reference, in the next verse, to the alternative of gradual decay.
(3) Or the punishment may come to people away from their homes and humble them in their pride. It so happened to Abu Jahl, who came exulting in his pride to the Battle of Badr (A.H. 2). His army was three times the size of the Muslim army from Madinah. But it suffered a crushing defeat, and he himself was ignominiously slain.