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I.e., whatever good deeds they may do will be so completely outweighed by the above-mentioned sin that they will amount to nothing on the Day of judgment. (But see also note 9 below.) The above verse connects with the last sentence of the preceding surah, "Will, then, any be [really] destroyed save iniquitous folk?"
Whatever they do will miss its mark, because Allah is the source of all energy and life. If the wicked try to persecute men or seduce them from the Truth, the result will be the opposite of what they intend.