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The verb barama or abrama signifies, literally, "he twined" or "twisted [something] together", e.g., the strands that are to form a rope; or "he twisted [something] well" or "strongly". Tropically, it connotes the act of "establishing" or "determining" a thing, a proposition, a course of events, etc. (Jawhari). According to the Lisan a -'Arab, the phrase abrama al-amr has the meaning of "he determined (ahkama) the case". In the present context, the term amr, having no definite article, signifies "anything" or - in its widest sense - "anything that should [or "could"] be": and so, taking the preceding verse into account, we arrive at the meaning of arbitrarily "determining what [the truth] should be" - i.e., in contradiction to what the Qur'an postulates as the truth.
Men cannot settle the high affairs of the universe. If they plot against the Truth, the Truth will destroy them, just as, if they accept the Truth, the Truth will make them free. It is Allah Who disposes of affairs.