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A reference to the persistent Jewish belief that they alone among all nations have been graced by divine revelation. The "trifling gain" is their conviction that they are "God's chosen people" - a claim which the Qur'an consistently refutes.
Trading Allah’s revelations for a fleeting gain is a recurring theme in the first few sûrahs of the Quran. This refers to the practice of some Jewish authorities in Medina who contradicted certain rulings in the Torah by giving people lenient opinions only to please them in exchange for money.
You receive revelations before: now comes one confirming it: its first appeal should be to you: are you to be the first to reject it? And reject it for what? God's Signs are worth more than all your paltry considerations. And the standard of duty and righteousness is to be taken from God, and not from priests and customs.