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Cf. {6:131-132}. In the wider sense of this expression, the "forefathers" may be a metonym for a community's cultural past: hence, the reference to those "forefathers" not having been "warned" (i.e., against evil) evidently alludes to the defectiveness of the ethical heritage of people who have become estranged from true moral values.
The Quraish had received no Prophet before, and therefore one of themselves was made the vehicle for the universal Message to the whole world.